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Drug interaction
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=== Mechanisms === The mechanisms underlying most herb-drug interactions are not fully understood.<ref>{{cite journal|last1=Chen|first1=XW|last2=Sneed|first2=KB|last3=Pan|first3=SY|last4=Cao|first4=C|last5=Kanwar|first5=JR|last6=Chew|first6=H|last7=Zhou|first7=SF|date=1 June 2012|title=Herb-drug interactions and mechanistic and clinical considerations.|journal=Current Drug Metabolism|volume=13|issue=5|pages=640β51|doi=10.2174/1389200211209050640|pmid=22292789}}</ref> Interactions between herbal medicines and anticancer drugs typically involve enzymes that metabolize [[cytochrome P450]].<ref name="oncologist2" /> For example, St. John's Wort has been shown to induce [[CYP3A4]] and [[P-glycoprotein]] in vitro and in vivo.<ref name="oncologist2" />
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