Editing Human chorionic gonadotropin (section)

====Use in males====
In males, hCG injections are used to stimulate the [[Leydig cell]]s to synthesize [[testosterone]].<ref>{{cite journal | vauthors = Riccetti L, De Pascali F, Gilioli L, Potì F, Giva LB, Marino M, Tagliavini S, Trenti T, Fanelli F, Mezzullo M, Pagotto U, Simoni M, Casarini L | title = Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro | journal = Reproductive Biology and Endocrinology | volume = 15 | issue = 1 | pages = 2 | date = January 2017 | pmid = 28056997 | doi = 10.1186/s12958-016-0224-3 | pmc = 5217336 | doi-access = free }}</ref> The intratesticular testosterone is necessary for [[spermatogenesis]] from the [[sertoli cells]]. Typical medical uses for hCG in males include treating certain types of [[hypogonadism]] (either as monotherapy, or, more commonly, in combination with [[Testosterone (medication)|exogenous testosterone]]), as well as to either treat or prevent infertility, for example, during testosterone replacement therapy hCG is often used to restore or maintain fertility and prevent testicular atrophy.<ref>{{cite journal | vauthors = Kim ED, Crosnoe L, Bar-Chama N, Khera M, Lipshultz LI | title = The treatment of hypogonadism in men of reproductive age | journal = Fertility and Sterility | volume = 99 | issue = 3 | pages = 718–724 | date = March 2013 | pmid = 23219010 | doi = 10.1016/j.fertnstert.2012.10.052 | doi-access = free }}</ref><ref name="e876">{{cite journal | vauthors = Lee JA, Ramasamy R | title = Indications for the use of human chorionic gonadotropic hormone for the management of infertility in hypogonadal men | journal = Translational Andrology and Urology | volume = 7 | issue = Suppl 3 | pages = S348–S352 | date = July 2018 | pmid = 30159241 | doi = 10.21037/tau.2018.04.11 | publisher = AME Publishing Company | doi-access = free | pmc = 6087849 }}</ref>