Editing Iron overload (section)

===Genetics===

General screening for hemochromatosis is not recommended, however [[first-degree relatives]] of those affected should be screened.<ref name="NEJM Olynyk" /><ref name="AFP2013">{{cite journal|last=Crownover|first=BK|author2=Covey, CJ|date=Feb 1, 2013|title=Hereditary hemochromatosis.|journal=American Family Physician|volume=87|issue=3|pages=183–90|pmid=23418762}}</ref><ref name="AASLD guidelines" /><ref name="ACG guidelines" />

Once iron overload has been established, [[HFE gene|''HFE'' gene]] mutation [[genetic testing]] for hereditary causes of iron overload is indicated.<ref name="AASLD guidelines" /><ref name="pmid20542038" /> The presence of ''HFE'' gene mutations in addition to iron overload confirms the clinical diagnosis of hereditary hemochromatosis type 1.<ref name="AASLD guidelines" /> The alleles evaluated by ''HFE'' gene analysis are mutated (C282Y/C282Y; C282Y/H63D; C282Y/S65C; H63D/H63D) in 80-90% of patients with hereditary hemochromatosis; a negative report for these mutations of HFE gene does not rule out hemochromatosis.{{citation needed|date=June 2023}}