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Liver function tests
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===Coagulation test=== The liver is responsible for the production of the vast majority of [[coagulation]] factors. In patients with liver disease, [[international normalized ratio]] (INR) can be used as a marker of liver synthetic function as it includes [[factor VII]], which has the shortest half life (2β6 hours) of all coagulation factors measured in INR. An elevated INR in patients with liver disease, however, does not necessarily mean the patient has a tendency to bleed, as it only measures procoagulants and not anticoagulants. In liver disease the synthesis of both are decreased and some patients are even found to be hypercoagulable (increased tendency to clot) despite an elevated INR. In liver patients, coagulation is better determined by more modern tests such as [[thromboelastogram]] (TEG) or thomboelastrometry (ROTEM).{{citation needed|date=November 2021}} Prothrombin time (PT) and its derived measures of prothrombin ratio (PR) and INR are measures of the [[Coagulation#Tissue factor pathway (extrinsic)|extrinsic pathway]] of [[coagulation]]. This test is also called "ProTime INR" and "INR PT". They are used to determine the clotting tendency of blood, in the measure of [[warfarin]] dosage, liver damage, and [[vitamin K]] status.<ref>{{Cite web|title=Prothrombin Time Test and INR (PT/INR): MedlinePlus Medical Test|url=https://medlineplus.gov/lab-tests/prothrombin-time-test-and-inr-ptinr/|access-date=2021-02-25|website=medlineplus.gov|language=en}}</ref>
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