Editing Peripheral neuropathy (section)

==== Antidepressants ====
In general, according to Cochrane's systematic reviews, antidepressants have shown to either be ineffective for the treatment of neuropathic pain or the evidence available is inconclusive.<ref name=":0" /><ref name=":1">{{cite journal|vauthors=Hearn L, Moore RA, Derry S, Wiffen PJ, Phillips T|editor1-first=Leslie|editor1-last=Hearn|date=September 2014|title=Desipramine for neuropathic pain in adults|journal=The Cochrane Database of Systematic Reviews|volume=2014 |issue=9|pages=CD011003|doi=10.1002/14651858.CD011003.pub2|pmid=25246131|pmc=6804291}}</ref><ref name=":2">{{cite journal|vauthors=Gallagher HC, Gallagher RM, Butler M, Buggy DJ, Henman MC|date=August 2015|title=Venlafaxine for neuropathic pain in adults|journal=The Cochrane Database of Systematic Reviews|volume=2017|issue=8|pages=CD011091|doi=10.1002/14651858.CD011091.pub2|pmc=6481532|pmid=26298465}}</ref><ref name=":3">{{cite journal|vauthors=Derry S, Phillips T, Moore RA, Wiffen PJ|date=July 2015|title=Milnacipran for neuropathic pain in adults|journal=The Cochrane Database of Systematic Reviews|volume=2019 |issue=7|pages=CD011789|doi=10.1002/14651858.CD011789|pmc=6485877|pmid=26148202}}</ref> Evidence also tends to be tainted by bias or issues with the methodology.<ref name=":4">{{cite journal|vauthors=Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ|date=July 2015|editor-last=Cochrane Pain, Palliative and Supportive Care Group|title=Amitriptyline for neuropathic pain in adults|journal=The Cochrane Database of Systematic Reviews|volume=2015 |issue=7|pages=CD008242|doi=10.1002/14651858.CD008242.pub3|pmc=6447238|pmid=26146793}}</ref><ref name=":5">{{cite journal|vauthors=Hearn L, Derry S, Phillips T, Moore RA, Wiffen PJ|date=May 2014|title=Imipramine for neuropathic pain in adults|journal=The Cochrane Database of Systematic Reviews|volume=2019 |issue=5|pages=CD010769|doi=10.1002/14651858.CD010769.pub2|pmc=6485593|pmid=24838845}}</ref>

Cochrane systematically reviewed the evidence for the antidepressants nortriptyline, desipramine, venlafaxine, and milnacipran and in all these cases found scant evidence to support their use for the treatment of neuropathic pain. All reviews were done between 2014 and 2015.<ref name=":0" /><ref name=":1" /><ref name=":2" /><ref name=":3" />

A 2015 Cochrane systematic review of amitriptyline found no evidence supporting [[amitriptyline]] that did not possess inherent bias. The authors believe amitriptyline may have an effect in some patients but that the effect is overestimated.<ref name=":4" /> A 2014 Cochrane systematic review of imipramine notes that the evidence suggesting benefit were "methodologically flawed and potentially subject to major bias."<ref name=":5" />

A 2017 Cochrane systematic review assessed the benefit of antidepressant medications for several types of chronic non-cancer pains (including neuropathic pain) in children and adolescents and the authors found the evidence inconclusive.<ref>{{cite journal | vauthors = Cooper TE, Heathcote LC, Clinch J, Gold JI, Howard R, Lord SM, Schechter N, Wood C, Wiffen PJ | title = Antidepressants for chronic non-cancer pain in children and adolescents | journal = The Cochrane Database of Systematic Reviews | volume = 8 | pages = CD012535 | date = August 2017 | issue = 8 | pmid = 28779487 | pmc = 6424378 | doi = 10.1002/14651858.CD012535.pub2 }}</ref>