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Post-translational modification
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===Common PTMs by frequency=== In 2011, statistics of each post-translational modification experimentally and putatively detected have been compiled using proteome-wide information from the Swiss-Prot database.<ref>{{cite journal | vauthors = Khoury GA, Baliban RC, Floudas CA | title = Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database | journal = Scientific Reports | volume = 1 | issue = 90 | pages = 90 | date = September 2011 | pmid = 22034591 | pmc = 3201773 | doi = 10.1038/srep00090 | bibcode = 2011NatSR...1E..90K }}</ref> The 10 most common experimentally found modifications were as follows:<ref>{{cite web|url=http://selene.princeton.edu/PTMCuration/|title=Proteome-Wide Post-Translational Modification Statistics|website=selene.princeton.edu|access-date=2011-07-22|archive-url=https://web.archive.org/web/20120830234041/http://selene.princeton.edu/PTMCuration/|archive-date=2012-08-30|url-status=dead}}</ref> {| class="wikitable" !Frequency !Modification |- |58383 |[[Phosphorylation]] |- |6751 |[[Acetylation]] |- |5526 |[[N-linked glycosylation]] |- |2844 |[[#amidation|Amidation]] |- |1619 |[[Hydroxylation]] |- |1523 |[[Methylation]] |- |1133 |[[O-linked glycosylation]] |- |878 |[[Ubiquitin|Ubiquitylation]] |- |826 |[[Pyroglutamic acid|Pyrrolidone carboxylic acid]] |- |504 |[[Sulfation]] |}
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