Editing Protein structure (section)

==Protein folding==

{{expand section|date=April 2019}}

{{Main|Protein folding}}

As it is translated, polypeptides exit the [[ribosome]] mostly as a [[random coil]] and folds into its [[native state]].<ref>{{cite journal | vauthors = Zhang G, Ignatova Z | title = Folding at the birth of the nascent chain: coordinating translation with co-translational folding | journal = Current Opinion in Structural Biology | volume = 21 | issue = 1 | pages = 25–31 | date = February 2011 | pmid = 21111607 | doi = 10.1016/j.sbi.2010.10.008 }}</ref><ref name="Alberts">{{cite book|title=Molecular Biology of the Cell | edition = Fourth | vauthors = Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walters P |publisher=Garland Science|year=2002|isbn=978-0-8153-3218-3|location=New York and London|chapter=The Shape and Structure of Proteins|author-link=Bruce Alberts|chapter-url=https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=books&doptcmdl=GenBookHL&term=mboc4%5Bbook%5D+AND+372270%5Buid%5D&rid=mboc4.section.388}}</ref> The final structure of the protein chain is generally assumed to be determined by its amino acid sequence ([[Anfinsen's dogma]]).<ref name="Anfinsen">{{cite journal | vauthors = Anfinsen CB | title = The formation and stabilization of protein structure | journal = The Biochemical Journal | volume = 128 | issue = 4 | pages = 737–749 | date = July 1972 | pmid = 4565129 | pmc = 1173893 | doi = 10.1042/bj1280737 | author-link = Christian B. Anfinsen }}</ref>