Editing Baum–Welch algorithm (section)

=====Prokaryotic=====
The [[GLIMMER]] (Gene Locator and Interpolated Markov ModelER) software was an early [[locus (genetics)|gene-finding]] program used for the identification of coding regions in [[prokaryotic]] DNA.<ref name="GLIMMER paper">{{cite journal |last1=Salzberg |first1=Steven |first2=Arthur L. |last2=Delcher |first3=Simon |last3=Kasif |first4=Owen |last4=White |title=Microbial gene identification using interpolated Markov Models |journal=Nucleic Acids Research |year=1998 |volume=26 |issue=2 |pages=544–548 |doi=10.1093/nar/26.2.544 |pmid=9421513 |pmc=147303 }}</ref><ref name="GLIMMER web">{{cite web |title=Glimmer: Microbial Gene-Finding System |url=http://ccb.jhu.edu/software/glimmer/index.shtml |publisher=Johns Hopkins University - Center for Computational Biology }}</ref> GLIMMER uses Interpolated Markov Models (IMMs) to identify the [[exon|coding regions]] and distinguish them from the [[introns|noncoding DNA]]. The latest release (GLIMMER3) has been shown to have increased [[specificity (statistics)|specificity]] and accuracy compared with its predecessors with regard to predicting translation initiation sites, demonstrating an average 99% accuracy in locating 3' locations compared to confirmed genes in prokaryotes.<ref>{{cite journal |last1=Delcher |first1=Arthur |first2=Kirsten A. |last2=Bratke |first3=Edwin C. |last3=Powers |first4=Steven L. |last4=Salzberg |title=Identifying bacterial genes and endosymbiont DNA with Glimmer |journal=Bioinformatics |year=2007 |volume=23 |issue=6 |pages=673–679 |doi=10.1093/bioinformatics/btm009 |pmid=17237039 |pmc=2387122 }}</ref>