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Electron ionization
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==== Forensic applications ==== The GC-EI-MS is also used in [[forensic science]]. One example is the analysis of five local [[Anesthesia|anesthetics]] in blood using [[Headspace gas chromatography for dissolved gas measurement|headspace]] solid-phase [[Microextraction by packed sorbent|microextraction]] (HS-SPME) and gas chromatography–mass spectrometry–electron impact ionization selected ion monitoring (GC–MS–EI-SIM). Local anesthesia is widely used but sometimes these drugs can cause medical accidents. In such cases an accurate, simple, and rapid method for the analysis of local anesthetics is required. GC-EI-MS was used in one case with an analysis time of 65 minutes and a sample size of approximately 0.2 g, a relatively small amount.<ref>{{Cite journal|last1=Watanabe|first1=Tomohiko|last2=Namera|first2=Akira|last3=Yashiki|first3=Mikio|last4=Iwasaki|first4=Yasumasa|last5=Kojima|first5=Tohru|date=1998-05-29|title=Simple analysis of local anaesthetics in human blood using headspace solid-phase microextraction and gas chromatography–mass spectrometry–electron impact ionization selected ion monitoring|journal=Journal of Chromatography B|volume=709|issue=2|pages=225–232|doi=10.1016/S0378-4347(98)00081-4|pmid=9657219}}</ref> Another application in forensic practice is the determination of [[date rape drug]]s (DRDs) in urine. These drugs are used to incapacitate victims and then rape or rob them. The analyses of these drugs are difficult due to the low concentrations in the body fluids and often a long time delay between the event and clinical examination. However, using GC-EI-MS allows a simple, sensitive and robust method for the identification, detection and quantification of 128 compounds of DRDs in urine.<ref>{{Cite journal|last1=Adamowicz|first1=Piotr|last2=Kała|first2=Maria|title=Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography–electron ionization-mass spectrometry|journal=Forensic Science International|volume=198|issue=1–3|pages=39–45|doi=10.1016/j.forsciint.2010.02.012|pmid=20207513|date=May 2010}}</ref>
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