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Essential tremor
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====Other second-line medications==== Additional medications that have been reported to show efficacy in treating ET are [[gabapentin]], [[benzodiazepines]] such as [[alprazolam]], [[clonazepam]], and [[zonisamide]], and [[pregabalin]].<ref name=":0" /> However, most of the medications have limited evidence-based to support their clinical usage as treatments for ET. Some systematic reviews of medications for the treatment of ET have been conducted. A 2017 review of [[topiramate]] found limited data and low-quality evidence to support its efficacy and the occurrence of treatment-limiting adverse effects,<ref>{{cite journal | vauthors = Bruno E, Nicoletti A, Quattrocchi G, Allegra R, Filippini G, Colosimo C, Zappia M | title = Topiramate for essential tremor | journal = The Cochrane Database of Systematic Reviews | volume = 2017 | issue = 4 | pages = CD009683 | date = April 2017 | pmid = 28409827 | pmc = 6478240 | doi = 10.1002/14651858.CD009683.pub2 }}</ref> a 2017 review of [[zonisamide]] found insufficient information to assess efficacy and safety,<ref>{{cite journal | vauthors = Bruno E, Nicoletti A, Filippini G, Quattrocchi G, Colosimo C, Zappia M | title = Zonisamide for essential tremor | journal = The Cochrane Database of Systematic Reviews | volume = 2017 | issue = 8 | pages = CD009684 | date = August 2017 | pmid = 28836659 | pmc = 6483684 | doi = 10.1002/14651858.CD009684.pub2 }}</ref> and a 2016 review of [[pregabalin]] determined the effects to be uncertain due to the low quality of evidence.<ref>{{cite journal | vauthors = Bruno E, Nicoletti A, Quattrocchi G, Filippini G, Colosimo C, Zappia M | title = Pregabalin for essential tremor | journal = The Cochrane Database of Systematic Reviews | volume = 10 | issue = 10 | pages = CD009682 | date = October 2016 | pmid = 27763691 | pmc = 6461190 | doi = 10.1002/14651858.CD009682.pub2 }}</ref>
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