Editing Frameshift mutation (section)

===Crohn's disease===

[[Crohn's disease]] has an association with the NOD2 gene. The mutation is an insertion of a [[Cytosine]] at position 3020. This leads to a premature stop codon, shortening the protein that is supposed to be transcribed. When the protein is able to form normally, it responds to bacterial liposaccharides, where the 3020insC mutation prevents the protein from being responsive.<ref>{{cite journal|vauthors=Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nuñez G, Cho JH |title=A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.|journal=Nature|date=May 31, 2001|volume=411|issue=6837|pages=603–6|pmid=11385577|doi=10.1038/35079114|bibcode=2001Natur.411..603O|hdl=2027.42/62856|s2cid=205017657|url=https://deepblue.lib.umich.edu/bitstream/2027.42/62856/1/411603a0.pdf|hdl-access=free}}</ref>