Editing Germ cell (section)

==Diseases==
[[Germ cell tumor]] is a rare [[cancer]] that can affect people at all ages. As of 2018, germ cell tumors account for 3% of all cancers in children and adolescents 0–19 years old.<ref>{{Cite web|url=https://curesearch.org/Number-of-Diagnoses|title=Number of Diagnoses {{!}} CureSearch|website=CureSearch for Children's Cancer|date=22 September 2014 |language=en-US|access-date=2019-09-27}}</ref>

Germ cell tumors are generally located in the [[gonad]]s but can also appear in the [[abdomen]], [[pelvis]], [[mediastinum]], or [[brain]]. Germ cells migrating to the gonads may not reach that intended destination and a tumor can grow wherever they end up, but the exact cause is still unknown. These tumors can be [[benign tumor|benign]] or [[malignant tumor|malignant]].<ref>{{cite web | title = Germ cell tumors| vauthors = Olson T |publisher=CureSearch.org |year=2006 |url= http://www.curesearch.org/for_parents_and_families/newlydiagnosed/article.aspx?ArticleId=3190&StageID=1&TopicId=1&Level=1 }}</ref>

On arrival at the gonad, primordial germ cells that do not properly differentiate may produce [[germ cell tumor]]s of the [[ovary]] or [[Testicle|testis]] in a [[mouse model]].<ref>{{cite journal | vauthors = Nicholls PK, Schorle H, Naqvi S, Hu YC, Fan Y, Carmell MA, Dobrinski I, Watson AL, Carlson DF, Fahrenkrug SC, Page DC | display-authors = 6 | title = Mammalian germ cells are determined after PGC colonization of the nascent gonad | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 116 | issue = 51 | pages = 25677–25687 | date = December 2019 | pmid = 31754036 | pmc = 6925976 | doi = 10.1073/pnas.1910733116 | bibcode = 2019PNAS..11625677N | doi-access = free }}</ref>