Editing Hashimoto's thyroiditis (section)

==== Medications ====
Certain medications or drugs have been associated with altering and interfering with thyroid function. There are two main mechanisms of interference:<ref name="Surks-1995" />

* Altering thyroid hormone serum transfer proteins.<ref name="Surks-1995">{{cite journal | vauthors = Surks MI, Sievert R | title = Drugs and thyroid function | journal = The New England Journal of Medicine | volume = 333 | issue = 25 | pages = 1688–1694 | date = December 1995 | pmid = 7477223 | doi = 10.1056/NEJM199512213332507 | veditors = Wood AJ }}</ref> [[Estrogen]], [[tamoxifen]], [[heroin]], [[methadone]], [[clofibrate]], [[Fluorouracil|5-fluorouracil]], [[mitotane]], and [[perphenazine]] all increase [[thyroid binding globulin]] (TBG) concentration.<ref name="Surks-1995" /> [[Androgen]]s, [[anabolic steroid]]s such as [[danazol]], glucocorticoids, and slow release [[nicotinic acid]] all decrease TBG concentrations. [[Furosemide]], fenoflenac, [[mefenamic acid]], [[salicylates]], [[phenytoin]], [[diazepam]], [[sulphonylureas]], [[free fatty acids]], and [[heparin]] all interfere with thyroid hormone binding to TBG and/or [[transthyretin]].<ref name="Surks-1995" />
* Altering extra-thryoidal metabolism of thyroid hormone. [[Propylthiouracil]], [[Glucocorticoid|glucocorticoids]], [[propranolol]], iondinated [[Contrast agent|contrast agents]], [[Amiodarone induced thyrotoxicosis|amiodarone]], and [[clomipramine]] all inhibit conversion of T<sub>4</sub> and T<sub>3</sub>.<ref name="Surks-1995" /> [[Phenobarbital]], [[Rifampicin|rifampin]], [[phenytoin]] and [[carbamazepine]] all increase [[hepatic]] metabolism.<ref name="Surks-1995" /> Finally, [[Colestyramine|cholestryamine]], [[colestipol]], [[aluminium hydroxide]], [[ferrous sulphate]], and [[sucralfate]] are all drugs that decrease T<sub>4</sub> absorption or enhance excretion.<ref name="Surks-1995" />