Editing Human chorionic gonadotropin (section)

====HCG Pubergen, Pregnyl warnings====
In the case of female patients who want to be treated with HCG Pubergen, Pregnyl:{{cn|date=August 2022}}
a) Since infertile female patients who undergo medically assisted reproduction (especially those who need [[In vitro fertilisation|in vitro fertilization]]), are known to often be suffering from<!-- !  check for tone !--> tubal abnormalities, after a treatment with this drug they might experience many more [[ectopic pregnancies]]. This is why early ultrasound confirmation at the beginning of a pregnancy (to see whether the pregnancy is intrauterine or not) is crucial. Pregnancies that have occurred after a treatment with this drug have a higher risk of [[multiple pregnancy]]. Female patients who have thrombosis, severe obesity, or thrombophilia should not be prescribed this medicine as they have a higher risk of arterial or venous thromboembolic events after or during a treatment with HCG Pubergen, Pregnyl. b)Female patients who have been treated with this medicine are usually more prone to pregnancy losses.{{cn|date=September 2023}}

In the case of male patients: A prolonged treatment with HCG Pubergen, Pregnyl is known to regularly lead to increased production of androgen. Therefore: Patients who have overt or latent cardiac failure, hypertension, renal dysfunction, migraines, or epilepsy might not be allowed to start using this medicine or may require a lower dose of HCG Pubergen, Pregnyl. This drug should be used with extreme caution in the treatment of [[prepubescent]] teenagers in order to reduce the risk of precocious sexual development or premature epiphyseal closure. This type of patients' skeletal maturation should be closely and regularly monitored.{{cn|date=September 2023}}

Both male and female patients who have the following medical conditions must not start a treatment with HCG Pubergen, Pregnyl: (1) Hypersensitivity to this drug or to any of its main ingredients. (2) Known or possible androgen-dependent tumors for example male breast carcinoma or prostatic carcinoma.