Editing Iron overload (section)

=== Biopsy ===
[[File:Kupffer cell with hemosiderin and hepatocyte with lipofuscin.jpg|thumb|[[Histopathology]] of the liver, showing [[Kupffer cell]]s with significant [[hemosiderin]] deposition (shown next to a hepatocyte with [[lipofuscin]] pigment, which is a common normal finding). H&E stain.]]
[[File:Kupffer cell with hemosiderin and hepatocyte with lipofuscin, iron stain.jpg|thumb|[[Prussian blue]] iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or portal macrophages) rather than parenchymal iron overload (within hepatocytes).<ref>Image by Mikael Häggström, MD. Source for mesenchymal versus parenchymal iron overload {{cite journal| author=Deugnier Y, Turlin B| title=Pathology of hepatic iron overload. | journal=World J Gastroenterol | year= 2007 | volume= 13 | issue= 35 | pages= 4755–60 | pmid=17729397 | doi=10.3748/wjg.v13.i35.4755 | pmc=4611197 | doi-access=free }}</ref>]]
The gold standard for confirming iron overload is the liver biopsy. [[Liver biopsy]] is the removal of small sample in order to be studied and can determine the cause of inflammation or cirrhosis. In someone with negative ''HFE'' gene testing, elevated iron status for no other obvious reason, and family history of liver disease, additional evaluation of liver iron concentration is indicated. In this case, diagnosis of hemochromatosis is based on biochemical analysis and histologic examination of a liver biopsy.{{citation needed|date=November 2021}}