Editing Nephron (section)

==Clinical significance==
Patients in early stages of [[chronic kidney disease]] show an approximate 50% reduction in the number of nephrons, comparable to the nephron loss that occurs with [[Ageing|aging]] (between ages 18–29 and 70–75).<ref name="pmid30455427">{{cite journal | vauthors = Kuro-O M | title = The Klotho proteins in health and disease | journal = Nature Reviews. Nephrology | volume = 15 | issue = 1 | pages = 27–44 | date = January 2019 | pmid = 30455427 | doi = 10.1038/s41581-018-0078-3 | s2cid = 53872296 }}</ref>

Diseases of the nephron predominantly affect either the glomeruli or the tubules. Glomerular diseases include [[diabetic nephropathy]], [[glomerulonephritis]] and [[IgA nephropathy]]; renal tubular diseases include [[acute tubular necrosis]], [[renal tubular acidosis]], and [[polycystic kidney disease]].