Editing RNA splicing (section)

==Splicing response to DNA damage==

[[DNA damage (naturally occurring)|DNA damage]] affects splicing factors by altering their [[post-translational modification]], localization, expression and activity.<ref name="pmid26529031">{{cite journal | vauthors = Shkreta L, Chabot B | title = The RNA Splicing Response to DNA Damage | journal = Biomolecules | volume = 5 | issue = 4 | pages = 2935–2977 | date = October 2015 | pmid = 26529031 | pmc = 4693264 | doi = 10.3390/biom5042935 | doi-access = free }}</ref>  Furthermore, DNA damage often disrupts splicing by interfering with its coupling to [[transcription (biology)|transcription]].  DNA damage also has an impact on the splicing and alternative splicing of genes intimately associated with [[DNA repair]].<ref name="pmid26529031" />  For instance, DNA damages modulate the alternative splicing of the DNA repair genes ''[[Brca1]]'' and ''[[ERCC1|Ercc1]]''.