Editing Small interfering RNA (section)

== Chemical modification ==
[[File:SiRNA mechanism.svg|thumb]]
siRNAs have been chemically modified to enhance their therapeutic properties, Short interfering RNA (siRNA) must be delivered to the site of action in the cells of target tissues in order for RNAi to fulfill its therapeutic promise. A detailed database of all such chemical modifications is manually curated as [http://crdd.osdd.net/servers/sirnamod siRNAmod] in scientific literature.<ref name=pmid26818131>{{cite journal | vauthors = Dar SA, Thakur A, Qureshi A, Kumar M | title = siRNAmod: A database of experimentally validated chemically modified siRNAs | journal = Scientific Reports | volume = 6 | issue = 1 | pages = 20031 | date = January 2016 | pmid = 26818131 | pmc = 4730238 | doi = 10.1038/srep20031 | bibcode = 2016NatSR...620031D }}</ref> Chemical modification of siRNA can also inadvertently result in loss of single-nucleotide specificity.<ref>{{cite journal | vauthors = Hickerson RP, Smith FJ, Reeves RE, Contag CH, Leake D, Leachman SA, Milstone LM, McLean WH, Kaspar RL | display-authors = 6 | title = Single-nucleotide-specific siRNA targeting in a dominant-negative skin model | journal = The Journal of Investigative Dermatology | volume = 128 | issue = 3 | pages = 594–605 | date = March 2008 | pmid = 17914454 | doi = 10.1038/sj.jid.5701060 | citeseerx = 10.1.1.465.8240 }}</ref>