Editing Structural bioinformatics (section)

=== Comparative modeling ===
[[Homology modeling|Comparative modeling]], also known as homology modeling, corresponds to the methodology to construct three-dimensional structures from an [[amino acid]] sequence of a target protein and a template with known structure. The literature has described that evolutionarily related proteins tend to present a conserved three-dimensional structure.<ref>{{Cite journal|last1=Kaczanowski|first1=Szymon|last2=Zielenkiewicz|first2=Piotr | name-list-style = vanc |date=March 2010|title=Why similar protein sequences encode similar three-dimensional structures?|journal=Theoretical Chemistry Accounts|language=en|volume=125|issue=3–6|pages=643–650|doi=10.1007/s00214-009-0656-3|s2cid=95593331|issn=1432-881X|url=http://eprints.ibb.waw.pl/21/1/publikcja1.pdf}}</ref> In addition, sequences of distantly related proteins with identity lower than 20% can present different folds.<ref>{{cite journal | vauthors = Chothia C, Lesk AM | title = The relation between the divergence of sequence and structure in proteins | journal = The EMBO Journal | volume = 5 | issue = 4 | pages = 823–6 | date = April 1986 | pmid = 3709526 | pmc = 1166865 | doi = 10.1002/j.1460-2075.1986.tb04288.x }}</ref>