Editing Transcriptome (section)

===Relation to proteome===
{{Further|Proteome}}
The transcriptome can be seen as a subset of the [[proteome]], that is, the entire set of proteins expressed by a genome.

However, the analysis of relative mRNA expression levels can be complicated by the fact that relatively small changes in mRNA expression can produce large changes in the total amount of the corresponding protein present in the cell. One analysis method, known as [[gene set enrichment analysis]], identifies coregulated gene networks rather than individual genes that are up- or down-regulated in different cell populations.{{ref|Subramanian}}

Although microarray studies can reveal the relative amounts of different mRNAs in the cell, levels of mRNA are not directly proportional to the expression level of the [[protein]]s they code for.<ref>{{cite journal |last=Schwanhäusser |first=Björn |journal=Nature |volume=473 |issue=7347 |pages=337–342 |pmid=21593866 |doi=10.1038/nature10098 |title=Global quantification of mammalian gene expression control |date=May 2011|bibcode=2011Natur.473..337S |s2cid=205224972 |display-authors=etal|url=http://edoc.mdc-berlin.de/11664/1/11664oa.pdf }}</ref> The number of protein molecules synthesized using a given mRNA molecule as a template is highly dependent on translation-initiation features of the mRNA sequence; in particular, the ability of the translation initiation sequence is a key determinant in the recruiting of [[ribosome]]s for protein [[translation (genetics)|translation]].