Editing Brain-derived neurotrophic factor (section)

=== Dendritogenesis ===

Local interaction of BDNF with the TrkB receptor on a single dendritic segment is able to stimulate an increase in PSD-95 trafficking to other separate dendrites as well as to the synapses of locally stimulated neurons.<ref name="pmid17515902">{{cite journal | vauthors = Yoshii A, Constantine-Paton M | title = BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation | journal = Nature Neuroscience | volume = 10 | issue = 6 | pages = 702–11 | date = June 2007 | pmid = 17515902 | doi = 10.1038/nn1903 | s2cid = 6486137 }}</ref> [[PSD-95]] localizes the actin-remodeling GTPases, [[Rac (GTPase)|Rac]] and [[Rho family of GTPases|Rho]], to synapses through the binding of its PDZ domain to [[kalirin]], increasing the number and size of spines.<ref name="pmid11182094">{{cite journal | vauthors = Penzes P, Johnson RC, Sattler R, Zhang X, Huganir RL, Kambampati V, Mains RE, Eipper BA | title = The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis | journal = Neuron | volume = 29 | issue = 1 | pages = 229–42 | date = January 2001 | pmid = 11182094 | doi = 10.1016/s0896-6273(01)00193-3 | s2cid = 7014018 | doi-access = free }}</ref> Thus, BDNF-induced trafficking of [[PSD-95]] to dendrites stimulates actin remodeling and causes dendritic growth in response to BDNF.