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Chloroform
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===Exposure=== Chloroform is formed as a by-product of [[water chlorination]], along with a range of other [[disinfection by-product]]s, and it is therefore often present in municipal tap water and swimming pools. Reported ranges vary considerably, but are generally below the current health standard for total [[trihalomethanes]] (THMs) of 100 ΞΌg/L.<ref>{{cite journal|last1=Nieuwenhuijsen|first1=MJ|last2=Toledano|first2=MB|last3=Elliott|first3=P|title=Uptake of chlorination disinfection by-products; a review and a discussion of its implications for exposure assessment in epidemiological studies.|journal=Journal of Exposure Analysis and Environmental Epidemiology|date=8 August 2000|volume=10|issue=6 Pt 1|pages=586β99|pmid=11140442|doi=10.1038/sj.jea.7500139|doi-access=free}}</ref> However, when considered in combination with other trihalomethanes often present in drinking water, the concentration of THMs often exceeds the recommended limit of exposure.<ref>{{Cite web |title=EWG's Tap Water Database: Contaminants in Your Water |url=https://www.ewg.org/tapwater/reviewed-disinfection-byproducts.php |access-date=2023-08-08 |website=www.ewg.org |language=en}}</ref> Historically, chloroform exposure may well have been higher, owing to its common use as an anesthetic, as an ingredient in cough syrups, and as a constituent of [[tobacco smoke]], where [[DDT]] had previously been used as a [[fumigant]].<ref>Yin-Tak Woo, David Y. Lai, Joseph C. Arcos [https://books.google.com/books?id=25H-BAAAQBAJ&dq=Chloroform+tobacco&pg=PA98 Aliphatic and Polyhalogenated Carcinogens: Structural Bases and Biological] {{webarchive|url=https://web.archive.org/web/20180605033237/https://books.google.com/books?id=25H-BAAAQBAJ&pg=PA98&lpg=PA98&dq=Chloroform+tobacco&source=bl&ots=GGoHCH5uup&sig=vJAm_Ecl4J_XuHn5EXIZ9Jpik4E&hl=en&sa=X&ved=0ahUKEwjPrLX9hbvUAhXDDsAKHeIOC3gQ6AEILzAC |date=5 June 2018 }}</ref>
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