Editing Essential tremor (section)

==== Botulinum Toxin (BoNT) ====
[[Botulinum toxin]] is a neurotoxin produced by a gram-positive, rod-shaped bacteria called [[Clostridium botulinum]]. BoNT works by inhibiting acetylcholine release at the presynaptic terminal by inactivating the SNARE proteins (SNAP-25), which interfere with muscle contraction.<ref>{{cite journal | vauthors = Anandan C, Jankovic J | title = Botulinum Toxin in Movement Disorders: An Update | journal = Toxins | volume = 13 | issue = 1 | pages = 42 | date = January 2021 | pmid = 33430071 | pmc = 7827923 | doi = 10.3390/toxins13010042 | doi-access = free }}</ref> BoNT type A injections have shown benefits in several clinical trials for the treatments of limb, voice, and head. However, the associated side effects included muscle weakness, stiffness reported within studies of limb tremors, and neck muscle pain, weakness, and dysphagia in clinical trials of head tremors.<ref name=":8" /> Botulinum toxin type A has been found to be helpful in treating voice tremors.<ref>{{cite journal | vauthors = Adler CH, Bansberg SF, Hentz JG, Ramig LO, Buder EH, Witt K, Edwards BW, Krein-Jones K, Caviness JN | title = Botulinum toxin type A for treating voice tremor | journal = Archives of Neurology | volume = 61 | issue = 9 | pages = 1416–1420 | date = September 2004 | pmid = 15364688 | doi = 10.1001/archneur.61.9.1416 }}</ref>