Editing Interactome (section)

===Viral interactomes===
Viral protein interactomes consist of interactions among viral or phage proteins. They were among the first interactome projects as their genomes are small and all proteins can be analyzed with limited resources. Viral interactomes are connected to their host interactomes, forming virus-host interaction networks.<ref>{{cite journal |author=Navratil V.|title=VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks|journal=Nucleic Acids Res.|volume=37 |pages=D661–8|year=2009 |pmid= 18984613 |doi=10.1093/nar/gkn794 |last2=De Chassey |first2=B. |last3=Meyniel |first3=L. |last4=Delmotte |first4=S. |last5=Gautier |first5=C. |last6=Andre |first6=P. |last7=Lotteau |first7=V. |last8=Rabourdin-Combe |first8=C. |issue=Database issue |pmc=2686459|display-authors=1}}</ref> Some published virus interactomes include

'''Bacteriophage'''
* ''[[Escherichia coli]]'' [[Lambda phage|bacteriophage lambda]]<ref>{{cite journal |author=Rajagopala SV.|title=The protein interaction map of bacteriophage lambda|journal= BMC Microbiol.|volume=11 |pages=213|year=2011 |pmid= 21943085 |doi=10.1186/1471-2180-11-213 |pmc=3224144 |last2=Casjens |first2=Sherwood |last3=Uetz |first3=Peter|display-authors=1 |doi-access=free }} {{open access}}</ref>
* ''[[Escherichia coli]]'' [[T7 phage|bacteriophage T7]]<ref name="pmid8528255">{{cite journal |vauthors=Bartel PL, Roecklein JA, SenGupta D, Fields S |title=A protein linkage map of Escherichia coli bacteriophage T7 |journal=Nat. Genet. |volume=12 |issue=1 |pages=72–7 |year=1996 |pmid=8528255 |doi=10.1038/ng0196-72 |s2cid=37155819 }}</ref>
* ''[[Streptococcus pneumoniae]]'' bacteriophage Dp-1<ref>{{cite journal |author=Sabri M.|title=Genome annotation and intraviral interactome for the ''Streptococcus pneumoniae'' virulent phage Dp-1|journal=J. Bacteriol.|volume=193 |pages=551–62|year=2011 |pmid= 21097633 |doi=10.1128/JB.01117-10 |pmc=3019816 |issue=2 |last2=Hauser |first2=R. |last3=Ouellette |first3=M. |last4=Liu |first4=J. |last5=Dehbi |first5=M. |last6=Moeck |first6=G. |last7=Garcia |first7=E. |last8=Titz |first8=B. |last9=Uetz |first9=P.|display-authors=1}}</ref>
* ''[[Streptococcus pneumoniae]]'' bacteriophage Cp-1<ref>{{cite journal |author=Häuser R.|title=The proteome and interactome of ''Streptococcus pneumoniae'' phage Cp-1|journal=J. Bacteriol.|volume=193 |pages=3135–8|year=2011 |pmid= 21515781 |doi=10.1128/JB.01481-10 |pmc=3133188 |issue=12 |last2=Sabri |first2=M. |last3=Moineau |first3=S. |last4=Uetz |first4=P.|display-authors=1}}</ref>

The lambda and VZV interactomes are not only relevant for the biology of these viruses but also for technical reasons: they were the first interactomes that were mapped with multiple [[Y2H]] vectors, proving an improved strategy to investigate interactomes more completely than previous attempts have shown.

'''Human (mammalian) viruses'''
* Human [[varicella zoster virus]] (VZV)<ref>{{cite journal|last=Stellberger|first=T.|display-authors=etal|title=Improving the yeast two-hybrid system with permutated fusions proteins: the Varicella Zoster Virus interactome|journal=Proteome Sci.|year=2010|pmid=20205919|doi=10.1186/1477-5956-8-8|pmc=2832230|volume=8|pages=8 |doi-access=free }}</ref>
* [[Chandipura virus]]<ref name="Chandipura">{{Cite journal | last1 = Kumar | first1 = K. | last2 = Rana | first2 = J. | last3 = Sreejith | first3 = R. | last4 = Gabrani | first4 = R. | last5 = Sharma | first5 = S. K. | last6 = Gupta | first6 = A. | last7 = Chaudhary | first7 = V. K. | last8 = Gupta | first8 = S. | doi = 10.1007/s00705-012-1389-5 | title = Intraviral protein interactions of Chandipura virus | journal = Archives of Virology | volume = 157 | issue = 10 | pages = 1949–1957 | year = 2012 | pmid = 22763614 | s2cid = 17714252 }}</ref>
* [[Epstein-Barr virus]] (EBV)<ref name="Fossum 2009 e1000570" />
* [[Hepatitis C virus]] (HPC),<ref name="Hagen2014">{{Cite journal | pmid = 24797426 | year = 2014 | last1 = Hagen | first1 = N | title = The intra viral protein interaction network of hepatitis C virus | journal = Molecular & Cellular Proteomics | last2 = Bayer | first2 = K | last3 = Roesch | first3 = K | last4 = Schindler | first4 = M | doi = 10.1074/mcp.M113.036301 | volume=13 | issue=7 | pages=1676–89 | doi-access = free | pmc = 4083108 }}</ref> Human-HCV interactions<ref>{{cite journal | last1 = Han | first1 = Y | last2 = Niu | first2 = J | last3 = Wang | first3 = D | last4 = Li | first4 = Y | year = 2016 | title = Hepatitis C Virus Protein Interaction Network Analysis Based on Hepatocellular Carcinoma | journal = PLOS ONE | volume = 11 | issue = 4| page = e0153882 | doi = 10.1371/journal.pone.0153882| pmid = 27115606 | pmc = 4846009 | bibcode = 2016PLoSO..1153882H | doi-access = free }}</ref>
* [[Hepatitis E virus]] (HEV)<ref name="pmid26463011">{{cite journal |vauthors=Osterman A, Stellberger T, Gebhardt A, Kurz M, Friedel CC, Uetz P, Nitschko H, Baiker A, Vizoso-Pinto MG |title=The Hepatitis E virus intraviral interactome |journal=Sci Rep |volume=5 |pages=13872 |year=2015 |pmid=26463011 |pmc=4604457 |doi=10.1038/srep13872 |bibcode=2015NatSR...513872O }}</ref>
* [[Herpes simplex virus 1]] (HSV-1)<ref name="Fossum 2009 e1000570" />
* [[Kaposi's sarcoma-associated herpesvirus]] (KSHV)<ref name="Fossum 2009 e1000570">{{cite journal|last=Fossum|first=E|display-authors=etal|title=Evolutionarily conserved herpesviral protein interaction networks|journal=PLOS Pathog |year=2009|pmid=19730696|doi=10.1371/journal.ppat.1000570|pmc=2731838|volume=5|issue=9|pages=e1000570|editor1-last=Sun|editor1-first=Ren|doi-access=free}} {{open access}}</ref>
* Murine [[cytomegalovirus]] (mCMV)<ref name="Fossum 2009 e1000570" />