Editing Inverted repeat (section)

=== Osteogenesis imperfecta from a frameshift mutation ===
Mutations in the [[collagen]] gene can lead to the disease [[Osteogenesis Imperfecta]], which is characterized by brittle bones.<ref name=bissler /> In the illustration, a stem-loop formed from an imperfect inverted repeat is mutated with a thymine (T) nucleotide insertion as a result of an inter- or intrastrand switch. The addition of the T creates a [[base-pairing]] "match up" with the adenine (A) that was previously a "bump" on the left side of the stem. While this addition makes the stem stronger and perfects the inverted repeat, it also creates a [[frameshift mutation]] in the nucleotide sequence which alters the [[reading frame]] and will result in an incorrect expression of the gene.<ref name=bissler />
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