Editing Manx cat (section)

=== Identification of the Manx Cat tailless gene ===

In 2013, prior to initiation of the Manx Cat Genome Project (below), genetic mutations in the [[brachyury]] gene were shown to be responsible for failure of tail development in the Manx cat, as well as four other tailless breeds of cat.<ref>Mamm Genome. 2013 Oct;24(9-10):400-8. doi: 10.1007/s00335-013-9471-1. Epub 2013 Aug 15.</ref> Mutations in orthologs of this gene have been shown to cause tail-loss defects in a number of other species, notably the mouse. Mutations in the human version of the brachyury gene are associated with a range of neural tube defects.<ref>{{Cite web|url=https://www.omim.org/entry/601397|title = OMIM Entry - * 601397 - T-BOX TRANSCRIPTION FACTOR T; TBXT}}</ref>