Editing Monoamine transporter (section)

==Double and triple MAT agents ({{aka}} SNRIs and TRIs)==
Below are examples of drugs that act directly by inhibiting two or more MATs simultaneously. Serotonin-norepinephrine re-uptake inhibitors ([[Serotonin–norepinephrine reuptake inhibitor|SNRIs]]) act by blocking both SERTs and NETs. Triple re-uptake inhibitors ([[Triple reuptake inhibitors|TRIs]]) act by blocking DATs, NETs, and SERTs simultaneously. Most modern antidepressant drugs work on the principle of blocking re-uptake transporters. SSRI's such as Fluoxetine (Prozac) and SNRI's as with Venlafaxine are the main types of drugs given in first line depression and anxiety treatment.

* [[PRC200-SS]] is an example of an SNRI.
* [[JNJ-7925476]] is an example of a TRI
* [[nocaine]]-[[modafinil]] hybrids such as 16e<ref>{{cite journal | last1 = Zhou | first1 = J | last2 = He | first2 = R | last3 = Johnson | first3 = KM | last4 = Ye | first4 = Y | last5 = Kozikowski | first5 = AP | date = Nov 2004 | title = Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization | journal = Journal of Medicinal Chemistry | volume = 47 | issue = 24| pages = 5821–4 | doi = 10.1021/jm040117o | pmid = 15537337 | pmc=1395211}}</ref><ref name="pmid16335921">{{cite journal |vauthors=He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP |title=Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors |journal=J. Med. Chem. |volume=48 |issue=25 |pages=7970–9 |year=2005 |pmid=16335921 |doi=10.1021/jm050694s }}</ref>
* Blough (2002) showed that MATs exhibit a "remote phenyl binding domaine"<ref name="pmid12190324">{{cite journal |vauthors=Blough BE, Keverline KI, Nie Z, Navarro H, Kuhar MJ, Carroll FI |title=Synthesis and transporter binding properties of 3beta-[4′-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter |journal=J. Med. Chem. |volume=45 |issue=18 |pages=4029–37 |year=2002 |pmid=12190324|doi=10.1021/jm020098n}}</ref>