Editing Necrotizing fasciitis (section)

===Antibiotics===
Empiric antibiotics are usually initiated as soon as the diagnosis of NSTI has been made. They are then changed to culture-guided antibiotic therapy. In the case of NSTIs, empiric antibiotics are broad-spectrum, covering gram-positive (including MRSA), gram-negative, and anaerobic bacteria.<ref name="Hu2018">{{cite journal|last1=Hua|first1=C|last2=Bosc|first2=R|last3=Sbidian|first3=E|last4=De Prost|first4=N|last5=Hughes|first5=C|last6=Jabre|first6=P|last7=Chosidow|first7=O|last8=Le Cleach|first8=L|date=31 May 2018|title=Interventions for necrotizing soft tissue infections in adults|journal=The Cochrane Database of Systematic Reviews|volume=2018|issue=5|pages=CD011680|doi=10.1002/14651858.CD011680.pub2|pmid=29851032|pmc=6494525}}</ref> Often, a combination of [[clindamycin]], [[daptomycin]], IV [[vancomycin]], and [[gentamicin]] is used.<ref name="Hak2014" /> Gram-negative coverage may entail the use of [[Quinolone antibiotic|fluoroquinolones]], [[piperacillin/tazobactam]], or [[carbapenem]]s.<ref name="CDC2016" />

Despite multiple studies, there is no consensus on how long antibiotics should be given.<ref name=Hu2018/> Generally, antibiotics are administered until surgeons decide that no further debridement is needed, and the patient no longer shows any systemic signs of infection from a clinical and laboratory standpoint.<ref name="CDC2016" /> Evidence regarding the efficacy of treatment and adverse effects is also unclear.