Editing Node of Ranvier (section)

===Nodal regulation===
====Via αII-Spectrin====
[[Saltatory conduction]] in myelinated axons requires organization of the nodes of Ranvier, whereas voltage-gated sodium channels are highly populated.  Studies show that αII-Spectrin, a component of the cytoskeleton is enriched at the nodes and paranodes at early stages and as the nodes mature, the expression of this molecule disappears.<ref>{{cite journal | doi = 10.1016/j.cub.2007.01.071 |vauthors=Voas MG, Lyons DA, Naylor SG, Arana N, Rasband MN, Talbot WS |date=Mar 2007 | title = alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons | journal = Current Biology | pmid = 17331725 | volume = 17 | issue = 6| pages = 562–8 |s2cid=14537696 | doi-access = free |bibcode=2007CBio...17..562V }}</ref> It is also proven that αII-Spectrin in the axonal cytoskeleton is absolutely vital for stabilizing sodium channel clusters and organizing the mature node of Ranvier.

====Possible regulation via the recognition molecule OMgp====
It has been shown previously that OMgp (oligodendrocyte myelin glycoprotein) clusters at nodes of Ranvier and may regulate paranodal architecture, node length and axonal sprouting at nodes.<ref>{{cite journal|last=Huang|first=JK |author2=Phillips, GR |author3=Roth, AD |author4=Pedraza, L |author5=Shan, W |author6=Belkaid, W |author7=Mi, S |author8=Fex-Svenningsen, A |author9=Florens, L |author10=Yates III, JR |author11=Colman, DR |title=Glial membranes at the node of Ranvier prevent neurite outgrowth|journal=Science|year=2005|volume=310|issue=5755 |pages=1813–17|doi= 10.1126/science.1118313 |pmid=16293723|bibcode=2005Sci...310.1813H |s2cid=17410200 |doi-access=free }}</ref>  However, a follow-up study showed that the antibody used previously to identify OMgp at nodes crossreacts with another node-enriched component [[versican]] V2 and that OMgp is not required for the integrity of nodes and paranodes, arguing against the previously reported localization and proposed functions of OMgp at nodes.<ref>{{cite journal|last=Chang|first=KJ|author2=Susuki, K |author3=Dours-Zimmermann, MT |author4=Zimmermann, DR |author5= Rasband, MN |title=Oligodendrocyte myelin glycoprotein does not influence node of Ranvier structure or assembly|journal=J Neurosci|year=2010|volume=30|issue=43|pages=14476–81|doi=10.1523/JNEUROSCI.1698-10.2010 |pmid=20980605|pmc=2976578}}</ref>