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Omeprazole
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==Society and culture== === Economics === When Prilosec's U.S. patent expired in April 2001, AstraZeneca introduced esomeprazole (Nexium) as a patented replacement drug.<ref>{{cite news |title=Prilosec's Maker Switches Users To Nexium, Thwarting Generics | vauthors = Harris G |work=The Wall Street Journal |url=https://www.wsj.com/articles/SB1023326369679910840 |date=6 June 2002 |url-status=live |archive-url=https://web.archive.org/web/20170806181248/https://www.wsj.com/articles/SB1023326369679910840 |archive-date=6 August 2017}}</ref> Many companies introduced generics as AstraZeneca's patents expired worldwide, which are available under many brand names. Omeprazole was a subject of a patent litigation in the U.S.<ref>{{cite press release | title=AstraZeneca awarded damages in Prilosec patent litigation | website=AstraZeneca | date=3 December 2013 | url=https://www.astrazeneca.com/media-centre/press-releases/2013/astrazeneca-prilosec-patent-litigation-ruling-03122013.html | access-date=4 October 2023}}</ref> The invention involved application of two different coatings to a drug in pill form to ensure that the omeprazole did not disintegrate before reaching its intended site of action in stomach. Although the solution by means of two coatings was obvious, the patent was found valid, because the source of the problem was non-obvious and was discovered by the patentee.<ref>{{cite web | url=https://scholar.google.com/scholar_case?case=12553883911671736992&q=+In+re+Omeprazole+Patent+Litigation&hl=en&as_sdt=40000003 | title=IN RE OMEPRAZOLE PATENT LITIGATION, Court of Appeals, Federal Circuit 2011 - Google Scholar }}</ref> In September 2023, AstraZeneca announced it would pay $425 million to settle product liability litigations against Prilosec in the United States.<ref>{{cite news |date=3 October 2023 |title=AstraZeneca to pay $425 mln to settle Nexium, Prilosec litigation in US |work=Reuters |url=https://www.reuters.com/legal/astrazeneca-pay-425-mln-settle-nexium-prilosec-litigation-us-2023-10-03/ |access-date=3 October 2023}}</ref> === Brand names === Brand names include Losec, Prilosec, Zegerid, Miracid, and Omez.<ref name="Drugs.com international">{{cite web | title=Omeprazole international | website=Drugs.com | date=3 February 2020 | url=https://www.drugs.com/international/omeprazole.html | access-date=27 February 2020 | archive-date=28 February 2020 | archive-url=https://web.archive.org/web/20200228060551/https://www.drugs.com/international/omeprazole.html | url-status=live }}</ref><ref name=AHFS2015/>
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