Editing Partition coefficient (section)

=== Shake flask-type ===
The classical and most reliable method of log ''P'' determination is the ''shake-flask method'', which consists of dissolving some of the solute in question in a volume of octanol and water, then measuring the concentration of the solute in each solvent.<ref name = "Dearden_1988">{{cite journal | vauthors = Dearden JC, Bresnan GM | title = The Measurement of Partition Coefficients | journal = Quantitative Structure-Activity Relationships | date = 1988 | volume = 7 | issue = 3 | pages = 133–144 | doi = 10.1002/qsar.19880070304 }}</ref><ref name = "Andrés_2015">{{cite journal | vauthors = Andrés A, Rosés M, Ràfols C, Bosch E, Espinosa S, Segarra V, Huerta JM | title = Setup and validation of shake-flask procedures for the determination of partition coefficients (log ''D'') from low drug amounts | journal = European Journal of Pharmaceutical Sciences | volume = 76 | pages = 181–91 | date = August 2015 | pmid = 25968358 | doi = 10.1016/j.ejps.2015.05.008 | hdl = 2445/143737 | hdl-access = free }}</ref> The most common method of measuring the distribution of the solute is by [[UV/VIS spectroscopy]].<ref name = "Dearden_1988"/>