Editing Reactive oxygen species (section)

===Cell proliferation===
Uncontrolled proliferation is a hallmark of cancer cells. Both exogenous and endogenous ROS have been shown to enhance proliferation of cancer cells. The role of ROS in promoting tumor proliferation is further supported by the observation that agents with potential to inhibit ROS generation can also inhibit cancer cell proliferation.<ref name="pmid22117137" /> Although ROS can promote tumor cell proliferation, a great increase in ROS has been associated with reduced cancer cell proliferation by induction of G2/M cell cycle arrest; increased phosphorylation of [[aTM serine/threonine kinase|ataxia telangiectasia mutated]] (ATM), checkpoint kinase 1 (Chk 1), Chk 2; and reduced cell division cycle 25 homolog c (CDC25).<ref>{{Cite journal |vauthors=Ames BN |date=September 1983 |title=Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases |journal=Science |volume=221 |issue=4617 |pages=1256–1264 |bibcode=1983Sci...221.1256A |doi=10.1126/science.6351251 |pmid=6351251}}</ref>