Editing Tryptamine (section)

==Pharmacokinetics==
Tryptamine produced [[endogenous]]ly or [[peripheral administration|administered peripherally]] is readily able to cross the [[blood–brain barrier]] and enter the [[central nervous system]].<ref name="MurphyTamarkinGarrick1985">{{cite book | last1=Murphy | first1=D. L. | last2=Tamarkin | first2=L. | last3=Garrick | first3=N. A. | last4=Taylor | first4=P. L. | last5=Markey | first5=S. P. | title=Neuropsychopharmacology of the Trace Amines | chapter=Trace Indoleamines in the Central Nervous System | publisher=Humana Press | publication-place=Totowa, NJ | year=1985 | isbn=978-1-4612-9397-2 | doi=10.1007/978-1-4612-5010-4_36 | pages=343–360}}</ref><ref name="KellarCascio1986">{{cite book | last1=Kellar | first1=Kenneth J. | last2=Cascio | first2=Caren S. | title=Receptor Binding | chapter=Tryptamine and Phenylethylamine Recognition Sites in Brain | date=1986 | volume=4 | publisher=Humana Press | publication-place=New Jersey | isbn=0-89603-078-4 | doi=10.1385/0-89603-078-4:119 | pages=119–138}}</ref> This is in contrast to [[serotonin]], which is [[peripherally selective drug|peripherally selective]].<ref name="MurphyTamarkinGarrick1985" />

Tryptamine is [[drug metabolism|metabolized]] by [[monoamine oxidase]] (MAO) to form [[indole-3-acetic acid]] (IAA).<ref name="MurphyTamarkinGarrick1985" /><ref name="Jones1982" /><ref name="KellarCascio1986" /> Its metabolism is described as extremely rapid and its [[elimination half-life]] and [[duration of action|duration]] as very short.<ref name="Jones1982" /><ref name="BloughLandavazoDecker2014" /><ref name="ShulginShulgin1997" /><ref name="MartinSloan1970" /> In addition, its duration is described as shorter than that of [[dimethyltryptamine]] (DMT).<ref name="MartinSloan1977" /> Brain tryptamine levels are increased up to 300-fold by MAOIs in animals.<ref name="KellarCascio1986" /> In addition, the effects of [[exogenous]] tryptamine are strongly augmented by [[monoamine oxidase inhibitor]]s (MAOIs).<ref name="Jones1982" /><ref name="KellarCascio1986" />

Tryptamine is [[excretion|excreted]] in [[urine]] and its rate of urinary excretion has been reported to be [[pH]]-dependent.<ref name="MartinSloan1970" /><ref name="FranzenGross1965">{{cite journal | vauthors = Franzen F, Gross H | title = Tryptamine, N,N-dimethyltryptamine, N,N-dimethyl-5-hydroxytryptamine and 5-methoxytryptamine in human blood and urine | journal = Nature | volume = 206 | issue = 988 | pages = 1052 | date = June 1965 | pmid = 5839067 | doi = 10.1038/2061052a0 | bibcode = 1965Natur.206.1052F | url = }}</ref><ref name="Price1975">{{cite journal | vauthors = Price J | title = The dependence of tryptamine excretion on urinary pH | journal = Clin Chim Acta | volume = 65 | issue = 3 | pages = 339–342 | date = December 1975 | pmid = 1161 | doi = 10.1016/0009-8981(75)90259-4 | url = }}</ref>