Editing Brain-derived neurotrophic factor (section)

== Neurogenesis ==

Laboratory studies indicate that BDNF may play a role in [[neurogenesis]]. BDNF can promote protective pathways and inhibit damaging pathways in the NSCs and NPCs that contribute to the brain's neurogenic response by enhancing cell survival.  This becomes especially evident following suppression of TrkB activity.<ref name="Bartkowska_2007"/>  TrkB inhibition results in a 2–3 fold increase in cortical precursors displaying EGFP-positive condensed apoptotic nuclei and a 2–4 fold increase in cortical precursors that stained immunopositive for cleaved [[caspase-3]].<ref name="Bartkowska_2007"/>  BDNF can also promote NSC and NPC proliferation through [[Akt]] activation and [[Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase|PTEN]] inactivation.<ref name="pmid10400703">{{cite journal | vauthors = Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM | title = PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway | journal = The Journal of Biological Chemistry | volume = 274 | issue = 29 | pages = 20693–703 | date = July 1999 | pmid = 10400703 | doi = 10.1074/jbc.274.29.20693 | doi-access = free }}</ref> Some studies suggest that BDNF may promote neuronal differentiation.<ref name="Bartkowska_2007"/><ref name="pmid21432850">{{cite journal | vauthors = Bath KG, Akins MR, Lee FS | title = BDNF control of adult SVZ neurogenesis | journal = Developmental Psychobiology | volume = 54 | issue = 6 | pages = 578–89 | date = September 2012 | pmid = 21432850 | pmc = 3139728 | doi = 10.1002/dev.20546 }}</ref>