Editing Complement system (section)

== Modulation of the body by complement with infection ==
Excessive complement activity contributes to severe Covid-19 symptoms and disease.<ref>{{Cite journal |vauthors=Afzali B, Noris M, Lambrecht BN, Kemper C |date=February 2022 |title=The state of complement in COVID-19 |journal=Nature Reviews. Immunology |volume=22 |issue=2 |pages=77–84 |doi=10.1038/s41577-021-00665-1 |pmc=8672651 |pmid=34912108}}</ref>  Although complement is intended to protect the body systems, under stress there can be more damage than protection. Research has suggested that the complement system is manipulated during [[Human Immunodeficiency Virus|HIV]]/[[Acquired Immunodeficiency Syndrome|AIDS]], in a way that further damages the body.<ref>{{Cite journal |vauthors=Datta PK, Rappaport J |date=November 2006 |title=HIV and complement: hijacking an immune defense |journal=Biomedicine & Pharmacotherapy |volume=60 |issue=9 |pages=561–568 |doi=10.1016/j.biopha.2006.07.087 |pmid=16978830}}</ref>