Editing Distance matrix (section)

===== Fitch–Margoliash =====
The Fitch–Margoliash method uses a weighted [[least squares]] method for clustering based on genetic distance. Closely related sequences are given more weight in the tree construction process to correct for the increased inaccuracy in measuring distances between distantly related sequences. The least-squares criterion applied to these distances is more accurate but less efficient than the neighbor-joining methods. An additional improvement that corrects for correlations between distances that arise from many closely related sequences in the data set can also be applied at increased computational cost.<ref>{{Cite journal |last=Fitch |first=Walter M. |date=1967 |title=Construction of Phylogenetic Trees: A method based on mutation distances as estimated from cytochrome c sequences is of general applicability. |url=https://www.science.org/doi/10.1126/science.155.3760.279 |journal=Science |volume=155|issue=3760 |pages=279–284 |doi=10.1126/science.155.3760.279 |pmid=5334057 }}</ref>