Editing Infective endocarditis (section)

====Major criteria====
Positive blood culture with typical IE microorganism, defined as one of the following:<ref name="NEJM Review, Hoen" />
* Typical microorganism consistent with IE from two separate blood cultures, as noted below:
** [[Streptococcus viridans|Viridans-group streptococci]], or
** ''[[Streptococcus bovis]]'' including nutritional variant strains, or
** [[HACEK]] group, or
** ''[[Staphylococcus aureus]]'', or
** Community-acquired ''[[enterococci]]'', in the absence of a primary focus
* Microorganisms consistent with IE from persistently positive blood cultures defined as:
** Two positive cultures of blood samples drawn >12 hours apart, or
** Three or a majority of ≥four separate blood cultures (with first and last sample drawn at least one hour apart)
** ''[[Coxiella burnetii]]'' detected by at least one positive blood culture or [[IgG antibody]] titer for [[Q fever]] phase 1 antigen >1:800. This was previously a minor criterion
Evidence of endocardial involvement with positive echocardiogram is defined as
* Oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation, or
* Abscess, or
* New partial dehiscence of prosthetic valve or new valvular regurgitation (worsening or changing of preexisting murmur not sufficient)