Editing Node of Ranvier (section)

====Via αII-Spectrin====
[[Saltatory conduction]] in myelinated axons requires organization of the nodes of Ranvier, whereas voltage-gated sodium channels are highly populated.  Studies show that αII-Spectrin, a component of the cytoskeleton is enriched at the nodes and paranodes at early stages and as the nodes mature, the expression of this molecule disappears.<ref>{{cite journal | doi = 10.1016/j.cub.2007.01.071 |vauthors=Voas MG, Lyons DA, Naylor SG, Arana N, Rasband MN, Talbot WS |date=Mar 2007 | title = alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons | journal = Current Biology | pmid = 17331725 | volume = 17 | issue = 6| pages = 562–8 |s2cid=14537696 | doi-access = free |bibcode=2007CBio...17..562V }}</ref> It is also proven that αII-Spectrin in the axonal cytoskeleton is absolutely vital for stabilizing sodium channel clusters and organizing the mature node of Ranvier.