Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Vesicular monoamine transporter
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
===Mood disorders=== Studies using a genetic rodent model to understand clinical depression in humans suggest that VMAT2 genetic or functional alterations may be involved in depression.<ref>{{cite journal |vauthors=Schwartz K, Yadid G, Weizman A, Rehavi M | year = 2003 | title = Decreased limbic vesicular monoamine transporter 2 in a genetic rat model of depression | journal = Brain Res. | volume = 965 | issue = 1β2| pages = 174β179 | doi=10.1016/s0006-8993(02)04167-7| pmid = 12591135 | s2cid = 26761996 }}</ref> Reduced VMAT2 levels were identified in specific subregions of the [[striatum]] involved in clinical depression, including the [[nucleus accumbens]] shell but not the core, the [[ventral tegmental area]], and the [[substantia nigra]]'s [[pars compacta]]. The reduced VMAT2 protein levels were not accompanied by similar levels of VMAT2 mRNA alterations. Based on these findings, it has been proposed that VMAT2 activity is not altered at the level of genetic expression, but may be altered at the functional level in ways that may correlate with clinical depression.<ref name="Wimalasena, K. 2011"/>
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)