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Anterior cingulate cortex
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===PTSD=== An increasing number of studies are investigating the role of the ACC in [[post-traumatic stress disorder]]. PTSD diagnosis and related symptoms such as skin conductance response (SCR) to "potentially startling sounds" were found to be correlated with reduced ACC volume.<ref>{{cite journal | vauthors = Young DA, Chao L, Neylan TC, O'Donovan A, Metzler TJ, Inslicht SS | title = Association among anterior cingulate cortex volume, psychophysiological response, and PTSD diagnosis in a Veteran sample | journal = Neurobiology of Learning and Memory | volume = 155 | pages = 189β196 | date = November 2018 | pmid = 30086395 | pmc = 6361720 | doi = 10.1016/j.nlm.2018.08.006 }}</ref> Further, childhood trauma and executive dysfunction seem to correlate with reduced ACC connectivity to surrounding neural regions.<ref name="Silveira 499β509">{{cite journal | vauthors = Silveira S, Shah R, Nooner KB, Nagel BJ, Tapert SF, de Bellis MD, Mishra J | title = Impact of Childhood Trauma on Executive Function in Adolescence-Mediating Functional Brain Networks and Prediction of High-Risk Drinking | journal = Biological Psychiatry. Cognitive Neuroscience and Neuroimaging | volume = 5 | issue = 5 | pages = 499β509 | date = May 2020 | pmid = 32299789 | doi = 10.1016/j.bpsc.2020.01.011 | pmc = 8366521 }}</ref> In a longitudinal study, this reduced connectivity was able to predict high-risk drinking (binge drinking at least once per week for the past 12 months) up to four years later.<ref name="Silveira 499β509"/>
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