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Autopsy
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==In stroke== [[File:Gross pathology of an old cerebral stroke, annotated.jpg|thumb|Cavitation at gross pathology of an old stroke in the left posterior parietal lobe]] An autopsy of [[stroke]] may be able to establish the time taken from the onset of cerebral infarction to the time of death. Various microscopic findings are present at times from infarction as follows:<ref name="pmid19690757">{{cite journal|last1=Mărgăritescu |first1=O|last2=Mogoantă |first2=L|last3=Pirici |first3=I|last4=Pirici |first4=D|last5=Cernea |first5=D|last6=Mărgăritescu |first6=C| title=Histopathological changes in acute ischemic stroke. | journal=Rom J Morphol Embryol | year= 2009 | volume= 50 | issue= 3 | pages= 327–39 | pmid=19690757 | doi= | pmc= | url=https://www.researchgate.net/publication/26751521}}</ref> [[File:Histopathology of thalamus infarction at approximately 24 hours, high magnification, annotated.jpg|thumb|240px|Histopathology at high magnification of a normal neuron, and an ischemic stroke at approximately 24 hours on [[H&E stain]]: The neurons become hypereosinophilic and there is an infiltrate of [[neutrophil]]s. There is slight edema and loss of normal architecture in the surrounding [[neuropil]].]] {| class="wikitable" ! Finding !! Presence |- | Eosinophilic (red) neurons | 1–35 days |- | Polymorphonuclear leukocytes | 1–37 days |- | Other acute neuronal injuries | 1–60 days |- | Coagulative necrosis | 1 day – 5 years |- | Spongiosis of surrounding tissue | 1 day and older |- | Astrogliosis (gemistocytes) | 2 days and older |- | Neo-vascularization | 3 days and older |- | Hemosiderin pigment | 3 days and older |- | Mononuclear inflammatory cells | 3 days–50 years |- | Macrophages | 3 days–50 years |- | Cavitation | 12 days or older |} <gallery> File:Cortical pseudolaminar necrosis - lfb - very low mag.jpg|[[Micrograph]] showing [[cortical pseudolaminar necrosis]], a finding seen in strokes on [[medical imaging]] and at autopsy. [[LFB stain|H&E-LFB stain]]. File:Reactive astrocytes - lfb - high mag.jpg|[[Micrograph]] of the superficial [[cerebral cortex]] showing neuron loss and [[reactive astrocytes]] in a person that has had a stroke. [[LFB stain|H&E-LFB stain]]. </gallery>
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