Editing Brain-derived neurotrophic factor (section)

== Research ==
Preliminary research has focused on the possible links between BDNF and clinical conditions, such as [[clinical depression|depression]],<ref name="Cavaleri_2023">{{cite journal | vauthors = Cavaleri D, Moretti F, Bartoccetti A, Mauro S, Crocamo C, Carrà G, Bartoli F | title = The role of BDNF in major depressive disorder, related clinical features, and antidepressant treatment: Insight from meta-analyses | language = English | journal = Neuroscience and Biobehavioral Reviews | volume = 149 | page = 105159 | date = April 2023 | pmid = 37019247 | doi = 10.1016/j.neubiorev.2023.105159 | s2cid = 257915698 | department = Review | doi-access = free | hdl = 10281/412775 | hdl-access = free }}</ref> [[schizophrenia]],<ref name="pmid19720106">{{cite journal | vauthors = Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL, Chen DC, Kosten TR, Zhang XY | title = Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 33 | issue = 8 | pages = 1508–12 | date = November 2009 | pmid = 19720106 | doi = 10.1016/j.pnpbp.2009.08.011 | s2cid = 43300334 }}</ref> and [[Alzheimer's disease]].<ref name="pmid19498435">{{cite journal | vauthors = Zuccato C, Cattaneo E | author-link2=Elena Cattaneo | title = Brain-derived neurotrophic factor in neurodegenerative diseases | journal = Nature Reviews. Neurology | volume = 5 | issue = 6 | pages = 311–22 | date = June 2009 | pmid = 19498435 | doi = 10.1038/nrneurol.2009.54 | s2cid=30782827 }}</ref>

=== Schizophrenia ===
{{See also|Epigenetics of schizophrenia#Methylation of BDNF}}
Preliminary studies have assessed a possible relationship between [[schizophrenia]] and BDNF.<ref>{{cite journal | vauthors = Xiong P, Zeng Y, Wu Q, Han Huang DX, Zainal H, Xu X, Wan J, Xu F, Lu J | title = Combining serum protein concentrations to diagnose schizophrenia: a preliminary exploration | journal = The Journal of Clinical Psychiatry | volume = 75 | issue = 8 | pages = e794–801 | date = August 2014 | pmid = 25191916 | doi = 10.4088/JCP.13m08772 }}</ref> It has been shown that BDNF mRNA levels are decreased in cortical layers IV and V of the dorsolateral prefrontal cortex of schizophrenic patients, an area associated with working memory.<ref>{{cite journal | vauthors = Ray MT, Shannon Weickert C, Webster MJ | title = Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders | journal = Translational Psychiatry | volume = 4 | issue = 5 | pages = e389 | date = May 2014 | pmid = 24802307 | pmc = 4035720 | doi = 10.1038/tp.2014.26 }}</ref>

=== Depression ===
{{See also|Epigenetics of depression#Brain-derived neurotrophic factor}}
The neurotrophic hypothesis of depression states that depression is associated with a decrease in the levels of BDNF.<ref name=Cavaleri_2023/>

=== Epilepsy ===
Levels of both BDNF mRNA and BDNF protein are known to be up-regulated in [[epilepsy]].<ref name="pmid1815605">{{cite journal | vauthors = Gall C, Lauterborn J, Bundman M, Murray K, Isackson P | title = Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain | journal = Epilepsy Research. Supplement | volume = 4 | pages = 225–45 | year = 1991 | pmid = 1815605 }}</ref>