Editing Comparative genomic hybridization (section)

====Chromosomal aberrations====
[[Cri du Chat]] (CdC) is a syndrome caused by a partial deletion of the short arm of chromosome 5.<ref name="Levy,Dunn,Kern,Hirschhorn,Kardon">{{cite journal | vauthors = Levy B, Dunn TM, Kern JH, Hirschhorn K, Kardon NB | year = 2002 | title = Delineation of the dup5q phenotype by molecular cytogenetic analysis in a patient with dup5q/del 5p (Cri du Chat) | journal = Am J Med Genet | volume = 108 | issue = 3| pages = 192–197 | doi=10.1002/ajmg.10261| pmid = 11891684 }}</ref> Several studies have shown that conventional CGH is suitable to detect the deletion, as well as more complex chromosomal alterations. For example, Levy et al. (2002) reported an infant with a cat-like cry, the hallmark of CdC, but having an indistinct karyotype. CGH analysis revealed a loss of chromosomal material from 5p15.3 confirming the diagnosis clinically. These results demonstrate that conventional CGH is a reliable technique in detecting structural aberrations and, in specific cases, may be more efficient in diagnosing complex abnormalities.<ref name="Levy,Dunn,Kern,Hirschhorn,Kardon" />