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Complement system
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== Role in the brain == Research from over the last decade has shown that complement proteins of the classical complement pathway have an important role in [[synaptic pruning]] in the brain during early development.<ref>{{Cite journal |display-authors=6 |vauthors=Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B |date=May 2012 |title=Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner |journal=Neuron |volume=74 |issue=4 |pages=691β705 |doi=10.1016/j.neuron.2012.03.026 |pmc=3528177 |pmid=22632727}}</ref><ref>{{Cite journal |vauthors=Gomez-Arboledas A, Acharya MM, Tenner AJ |date=September 2021 |title=The Role of Complement in Synaptic Pruning and Neurodegeneration |journal=ImmunoTargets and Therapy |volume=10 |pages=373β386 |doi=10.2147/ITT.S305420 |pmc=8478425 |pmid=34595138 |doi-access=free}}</ref>
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