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Exercise physiology
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=== Other factors === Exercise fatigue has also been suggested to be affected by: * brain hyperthermia<ref>{{Cite journal |last=Nybo |first=L |year=2008 |title=Hyperthermia and fatigue |journal=Journal of Applied Physiology |volume=104 |issue=3 |pages=871β8 |doi=10.1152/japplphysiol.00910.2007 |pmid=17962572}}</ref> * [[glycogen]] depletion in brain cells<ref name="Dalsgaard, M. K. 2006" /><ref>{{Cite journal |last=Dalsgaard |first=MK |last2=Secher |first2=NH |year=2007 |title=The brain at work: A cerebral metabolic manifestation of central fatigue? |journal=Journal of Neuroscience Research |volume=85 |issue=15 |pages=3334β9 |doi=10.1002/jnr.21274 |pmid=17394258 |s2cid=23623274 |doi-access=free}}</ref> * depletion of muscle and liver glycogen ''(see "[[hitting the wall]]")''<ref>{{Cite journal |last=Smyth |first=Barry |date=2021-05-19 |title=How recreational marathon runners hit the wall: A large-scale data analysis of late-race pacing collapse in the marathon |journal=PLOS ONE |language=en |volume=16 |issue=5 |pages=e0251513 |bibcode=2021PLoSO..1651513S |doi=10.1371/journal.pone.0251513 |issn=1932-6203 |pmc=8133477 |pmid=34010308 |doi-access=free}}</ref> * [[reactive oxygen species]] impairing skeletal muscle function<ref>{{Cite journal |last=Ferreira |first=LF |last2=Reid |first2=MB |year=2008 |title=Muscle-derived ROS and thiol regulation in muscle fatigue |journal=Journal of Applied Physiology |volume=104 |issue=3 |pages=853β60 |doi=10.1152/japplphysiol.00953.2007 |pmid=18006866}}</ref> * reduced level of [[glutamate]] secondary to uptake of ammonia in the brain<ref name="Nybo, L. 2005" /> * Fatigue in [[Muscles of respiration|diaphragm and abdominal respiratory muscles]] limiting breathing<ref>{{Cite journal |last=Romer |first=LM |last2=Polkey |first2=MI |year=2008 |title=Exercise-induced respiratory muscle fatigue: Implications for performance |url=http://bura.brunel.ac.uk/handle/2438/10000 |journal=Journal of Applied Physiology |volume=104 |issue=3 |pages=879β88 |doi=10.1152/japplphysiol.01157.2007 |pmid=18096752}}</ref> * Impaired oxygen supply to muscles<ref>{{Cite journal |last=Amann |first=M |last2=Calbet |first2=JA |year=2008 |title=Convective oxygen transport and fatigue |url=http://cris.ulpgc.es/jspui/bitstream/10553/6567/5/Convective_oxygen_transport.pdf |journal=Journal of Applied Physiology |volume=104 |issue=3 |pages=861β70 |doi=10.1152/japplphysiol.01008.2007 |pmid=17962570 |s2cid=22648694 |hdl-access=free |hdl=10553/6567}}</ref> * Ammonia effects upon the brain<ref name="Nybo, L. 2005" /> * [[Serotonin]] pathways in the brain<ref>{{Cite book |last=Newsholme |first=EA |title=Fatigue |last2=Blomstrand |first2=E |year=1995 |isbn=978-1-4899-1018-9 |series=Advances in Experimental Medicine and Biology |volume=384 |pages=315β20 |chapter=Tryptophan, 5-Hydroxytryptamine and a Possible Explanation for Central Fatigue |doi=10.1007/978-1-4899-1016-5_25 |pmid=8585461}}</ref>
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