Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Interactome
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
===Eukaryotic interactomes=== There have been several efforts to map eukaryotic interactomes through HTP methods. While no biological interactomes have been fully characterized, over 90% of proteins in ''Saccharomyces cerevisiae'' have been screened and their interactions characterized, making it the best-characterized interactome.<ref name="Schwikowski2000"/><ref name="Uetz2000">{{Cite journal | last1 = Uetz | first1 = P. | last2 = Giot | first2 = L. | last3 = Cagney | first3 = G. | last4 = Mansfield | first4 = T. A. | last5 = Judson | first5 = R. S. | last6 = Knight | first6 = J. R. | last7 = Lockshon | first7 = D. | last8 = Narayan | first8 = V. | title = A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae | journal = Nature | volume = 403 | issue = 6770 | pages = 623–627 | doi = 10.1038/35001009 | year = 2000 | pmid = 10688190 | bibcode = 2000Natur.403..623U | s2cid = 4352495 }}</ref><ref>{{cite journal |last =Krogan |first= NJ |display-authors=etal | year=2006|title = Global landscape of protein complexes in the yeast ''Saccharomyeses Cerivisiae ''| journal = Nature| volume= 440 |pages = 637–643|doi = 10.1038/nature04670 |pmid =16554755|issue =7084|bibcode=2006Natur.440..637K|s2cid= 72422 }}</ref> Species whose interactomes have been studied in some detail include * ''[[Schizosaccharomyces pombe]]''<ref name="pmid22540037">{{cite journal |vauthors=Pancaldi V, Saraç OS, Rallis C, McLean JR, Převorovský M, Gould K, Beyer A, Bähler J |title=Predicting the fission yeast protein interaction network |journal=G3: Genes, Genomes, Genetics |volume=2 |issue=4 |pages=453–67 |year=2012 |pmid=22540037 |pmc=3337474 |doi=10.1534/g3.111.001560 }}</ref><ref>{{cite journal | last1 = Vo | first1 = T.V. | display-authors = etal |year = 2016 | title = A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human | journal = Cell | volume = 164 | issue = 1–2| pages = 310–323 | doi = 10.1016/j.cell.2015.11.037 | pmid = 26771498 | pmc = 4715267}}</ref> * ''[[Caenorhabditis elegans]]'' * ''[[Drosophila melanogaster]]'' * ''Homo sapiens'' Recently, the pathogen-host interactomes of Hepatitis C Virus/Human (2008),<ref name="hcv">{{cite journal |author=de Chassey B |title=Hepatitis C virus infection protein network |journal=Molecular Systems Biology |date=2008-11-04 |volume=4 |issue= 4 |page=230 |pmid=18985028 |pmc=2600670 |doi=10.1038/msb.2008.66|author2= Navratil V |author3= Tafforeau L |display-authors=etal}}</ref> Epstein Barr virus/Human (2008), Influenza virus/Human (2009) were delineated through HTP to identify essential molecular components for pathogens and for their host's immune system.<ref name="vin">{{cite journal |author=Navratil V |title=Systems-level comparison of protein–protein interactions between viruses and the human type I interferon system network|journal=Journal of Proteome Research |volume=9 |issue=7 |pages=3527–36 |date=2010-11-05|pmid=20459142 |doi=10.1021/pr100326j|author2= de Chassey B|display-authors=etal}}</ref>
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)