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Peripheral neuropathy
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===Medical devices=== [[Transcutaneous electrical nerve stimulation]] (TENS) therapy is often used to treat various types of neuropathy. A 2010 review of three trials, for the treatment of diabetic neuropathy explicitly, involving a total of 78 patients found some improvement in pain scores after 4 and 6 but not 12 weeks of treatment and an overall improvement in neuropathic symptoms at 12 weeks.<ref>{{cite journal | vauthors = Jin DM, Xu Y, Geng DF, Yan TB | title = Effect of transcutaneous electrical nerve stimulation on symptomatic diabetic peripheral neuropathy: a meta-analysis of randomized controlled trials | journal = Diabetes Research and Clinical Practice | volume = 89 | issue = 1 | pages = 10β5 | date = July 2010 | pmid = 20510476 | doi = 10.1016/j.diabres.2010.03.021 }}</ref> Another 2010 review of four trials, for the treatment of diabetic neuropathy, found significant improvement in pain and overall symptoms, with 38% of patients in one trial becoming asymptomatic. The treatment remains effective even after prolonged use, but symptoms return to baseline within a month of cessation of treatment.<ref>{{cite journal | vauthors = Pieber K, Herceg M, Paternostro-Sluga T | title = Electrotherapy for the treatment of painful diabetic peripheral neuropathy: a review | journal = Journal of Rehabilitation Medicine | volume = 42 | issue = 4 | pages = 289β95 | date = April 2010 | pmid = 20461329 | doi = 10.2340/16501977-0554 | doi-access = free }}</ref> These older reviews can be balanced with a more recent 2017 review of TENS for neuropathic pain by Cochrane which concluded that "This review is unable to state the effect of TENS versus sham TENS for pain relief due to the very low quality of the included evidence... The very low quality of evidence means we have very limited confidence in the effect estimate reported." A very low quality of evidence means, 'multiple sources of potential bias' with a 'small number and size of studies'.<ref>{{cite journal | vauthors = Gibson W, Wand BM, O'Connell NE | title = Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults | journal = The Cochrane Database of Systematic Reviews | volume = 9 | pages = CD011976 | date = September 2017 | issue = 3 | pmid = 28905362 | pmc = 6426434 | doi = 10.1002/14651858.CD011976.pub2 }}</ref>
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