Editing Prenatal testing (section)

=== Digital PCR ===
Recently{{When|date=December 2023}}, it has been proposed that digital [[polymerase chain reaction|PCR]] analysis can be conducted on fetal cell-free DNA for detection of fetal aneuploidy. Research has shown that digital PCR can be used to differentiate between normal and aneuploid DNA.<ref name="Ref4">{{cite journal |vauthors=Zimmermann BG, Grill S, Holzgreve W, Zhong XY, Jackson LG, Hahn S |date=December 2008 |title=Digital PCR: a powerful new tool for noninvasive prenatal diagnosis? |journal=Prenatal Diagnosis |volume=28 |issue=12 |pages=1087–93 |doi=10.1002/pd.2150 |pmid=19003785 |s2cid=2909830 |doi-access=free}}</ref>

A variation of the PCR technique called [[multiplex ligation-dependent probe amplification]] (MLPA), targeting DNA, has been successively applied for diagnosing fetal aneuploidy as a chromosome- or gene-specific assay.<ref name="Attie2011">{{cite journal |vauthors=Go AT, van Vugt JM, Oudejans CB |year=2010 |title=Non-invasive aneuploidy detection using free fetal DNA and RNA in maternal plasma: recent progress and future possibilities |journal=Human Reproduction Update |volume=17 |issue=3 |pages=372–82 |doi=10.1093/humupd/dmq054 |pmid=21076134 |doi-access=free}}</ref>