Editing Prophase (section)

== Cell checkpoints ==
Prophase I in [[meiosis]] is the most complex iteration of prophase that occurs in both [[plant cell]]s and [[Cell (biology)|animal cells]].<ref name=":2" /> To ensure pairing of [[homologous chromosome]]s and [[Homologous recombination|recombination of genetic material]] occurs properly, there are [[Cell cycle checkpoint|cellular checkpoints]] in place. The meiotic checkpoint network is a [[DNA damage]] response system that controls [[DNA repair|double strand break]] repair, [[chromatin]] structure, and the movement and pairing of [[chromosome]]s.<ref>{{cite journal | vauthors = Hochwagen A, Amon A | title = Checking your breaks: surveillance mechanisms of meiotic recombination | journal = Current Biology | volume = 16 | issue = 6 | pages = R217-28 | date = March 2006 | pmid = 16546077 | doi = 10.1016/j.cub.2006.03.009 | doi-access = free | bibcode = 2006CBio...16.R217H }}</ref> The system consists of multiple pathways (including the [[meiotic recombination checkpoint]]) that prevent the cell from entering [[metaphase I]] with errors due to recombination.<ref>{{cite journal | vauthors = MacQueen AJ, Hochwagen A | title = Checkpoint mechanisms: the puppet masters of meiotic prophase | journal = Trends in Cell Biology | volume = 21 | issue = 7 | pages = 393–400 | date = July 2011 | pmid = 21531561 | doi = 10.1016/j.tcb.2011.03.004 }}</ref>