Editing Pyramidal cell (section)

=== Memory and learning ===
The hippocampus's pyramidal cells are essential for certain types of memory and learning. They form synapses that aid in the integration of synaptic voltages throughout their complex dendritic trees through interactions with [[Mossy fiber (hippocampus)|mossy fibers]] from [[Granule cell|granule cells]]. Since it affects the postsynaptic voltages produced by mossy fiber activation, the placement of [[thorny excrescence]]s on basal and apical dendrites is important for memory formation. By enabling dynamic control of the sensitivity of CA3 pyramidal cells, this clustering of mossy fiber synapses on pyramidal cells may facilitate the initiation of somatic spikes.

The interactions between pyramidal cells and an estimated 41 mossy fiber boutons, each originating from a unique granule cell, highlight the role of these boutons in information processing and synaptic connectivity, which are essential for memory and learning. Fundamentally, mossy fiber input is received by pyramidal cells in the hippocampus which integrate synaptic voltages within their dendritic architecture. The location of prickly protrusions and the clustering of synapses influence sensitivity and contribute to the processing of information pertaining to memory and learning.<ref>{{Cite journal |last1=Gonzales |first1=R. B. |last2=DeLeon Galvan |first2=C. J. |last3=Rangel |first3=Y. M. |last4=Claiborne |first4=B. J. |date=2001-02-12 |title=Distribution of thorny excrescences on CA3 pyramidal neurons in the rat hippocampus |url=https://pubmed.ncbi.nlm.nih.gov/11169473/ |journal=The Journal of Comparative Neurology |volume=430 |issue=3 |pages=357–368 |doi=10.1002/1096-9861(20010212)430:3<357::aid-cne1036>3.0.co;2-k |issn=0021-9967 |pmid=11169473}}</ref>